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  • NYU Dataset

    MicroRNA-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques

    Authors
    Milessa Silva Afonso
    Monika Sharma
    Martin Schlegel
    Coen van Solingen
    11 more author(s)...
    Description

    MicroRNA-33 (miR-33) targeted inhibition increases plasma HDL cholesterol and promotes atherosclerosis regression by enhancing reverse cholesterol transport and dampening plaque inflammation. This study showed how miR-33 inhibition alters the dynamic balance and transcriptional landscape of immune cells in atherosclerotic plaques. They used single cell RNA sequencing of aortic CD45+ cells, combined...

    Subject
    Genomics
    Access Rights
    Free to All