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  • NYU Dataset

    NYU Women's Health Study: Temporal Reproducibility of IgG and IgM Autoantibodies in Serum from Healthy Women

    Alternate Title(s)
    NYUWHS
    Authors
    Tess Clendenen
    Shaohui Hu
    Yelena Afanasyeva
    Manor Askenazi
    7 more author(s)...
    Description

    Study investigators examined blood samples from participants in the NYU Women’s Health Study (NYUWHS)--a cohort of 14,274 women enrolled between 1985 and 1991 through a breast cancer screening center in New York City--to identify autoantibodies associated with healthy women. The blood samples were collected at the time of enrollment and at annual screening visits until 1991 and long term follow-up...

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    Free to All
  • NYU Dataset

    Immune Responses Observed Before and After BNT162b2 mRNA Vaccine Administration in Individuals with and without History of SARS-CoV-2 Infection

    Authors
    Marie I. Samanovic
    Amber R. Cornelius
    Sophie L. Gray-Gaillard
    Joseph Richard Allen
    7 more author(s)...
    Description

    To study and compare longitudinal immune responses to two-dose BNT162b2 mRNA vaccinations, investigators recruited 15 adults with a history of laboratory-confirmed COVID-19 and 21 adults who did not have COVID-19. Participants' ages ranged from 21 to 65 years old. Peripheral immune responses were assessed via blood samples drawn before and after each vaccine dose. A total of five samples were collected...

    Subject
    COVID-19
    Infectious Disease
    Timeframe
    2021
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    Free to All
  • NYU Dataset

    Anti-DNA and Anti-Phosphatidylserine Antibodies Predicted Development of Severe COVID-19

    Authors
    Claudia Gomes
    Marisol Zuniga
    Kelly A. Crotty
    Kun Qian
    11 more author(s)...
    Description

    This is a retrospective cohort study of COVID-19 hospitalized patients with different degrees of severity. They performed this study to analyze the generation of autoimmune antibodies to common antigens. This study included 115 hospitalized patients with SARS-CoV-2 infection and 42 uninfected controls. Sample collection was performed as part of routine clinical care for COVID-19 patients at the time...

    Subject
    COVID-19
    Infectious Disease
    Timeframe
    2020
    Access Rights
    Free to All
  • NYU Dataset

    Autoimmunity to Annexin A2 Predicts Mortality Among Hospitalised COVID-19 Patients

    Authors
    Marisol Zuniga
    Claudia Gomes
    Steven E. Carsons
    Michael T. Bender
    4 more author(s)...
    Description

    This study examined autoimmune antibodies to annexin A2, which is a phospholipid-binding protein expressed in the lung and other organs, in COVID-19 patients. Annexin A2 is critical for fibrinolysis, lung elasticity, cell membrane repair, and integrity of the pulmonary vasculature. Therefore, antagonism of annexin A2 may explain many of the clinical features of severe COVID-19 cases. This study analyzed...

    Subject
    COVID-19
    Infectious Disease
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    Application Required
    Author Approval Required
  • NYU Dataset

    mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection

    Authors
    Ellie Ivanova
    Jasmine Shwetar
    Joseph C. Devlin
    Terkild B. Buus
    17 more author(s)...
    Description

    To investigate immune responses to SARS-CoV-2 antigens under various inflammatory conditions, researchers collected blood samples from five adult patients seen at NYU Langone Health with lab-confirmed cases of acute COVID-19 and from nine healthy adults (seven who had received the BNT162b2 mRNA vaccine and two with no prior exposure to SARS-CoV-2). Samples were obtained at multiple time points. Patients...

    Subject
    COVID-19
    Genomics
    Infectious Disease
    Access Rights
    Free to All
  • NYU Dataset

    Longitudinal study of immunity to SARS‐CoV2 in ocrelizumab‐treated MS patients up to 2 years after COVID‐19 vaccination

    Alternate Title(s)
    Vaccine‐generated Immunity in Ocrelizumab‐treated Patients: Longitudinal Assessments (VIOLA)
    Authors
    Ilya Kister
    Ryan Curtin
    Amanda L. Piquet
    Tyler Borko
    16 more author(s)...
    Description

    This is a prospective, two-year study of immunity against SARS-CoV-2 in multiple sclerosis patients receiving ocrelizumab (OCR) at the time of COVID vaccination. Researchers recruited 60 patients (aged 18-65) from the NYU MS Comprehensive Care Center in New York City and the Rocky Mountain MS Center at the University of Colorado Anschutz Medical Center in Aurora, CO. Participants provided blood samples...

    Subject
    Chronic Disease
    COVID-19
    Access Rights
    Free to All