NYU Data Catalog

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  • NYU Dataset

    KaryoCreate: A CRISPR-Based Technology to Study Chromosome-Specific Aneuploidy

    Authors
    Nazario Bosco
    Aleah Goldberg
    Xin Zhao
    Joseph C. Mays
    24 more author(s)...
    Description

    This study described karyotype CRISPR engineered aneuploidy technology (KaryoCreate), a system that enables generation of chromosome-specific aneuploidies by co-expression of an sgRNA targeting chromosome-specific CENPA-binding ɑ-satellite repeats together with dCas9 fused to mutant KNL1. They designed unique and highly specific sgRNAs for 19 of the 24 chromosomes. To examine the activity of the predicted...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Proteogenomic Analysis of Cancer Aneuploidy and Normal Tissues

    Authors
    Pan Cheng
    Xin Zhao
    Lizabeth Katsnelson
    Elaine M. Camacho-Hernandez
    9 more author(s)...
    Description

    This study performed a proteogenomic analysis of DNA, RNA and protein levels across primary tumor samples and cancer cell lines from different tumor types, a panel of isogenic non-tumorigenic human colon epithelial cells and normal tissues. They found tissue specificity in the RNA-level and protein-level compensation of genes are affected by somatic copy number alterations (SCNAs). Using the DNA–RNA...

    Subject
    Cancer
    Genomics
    Proteomics
    Access Rights
    Free to All