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  • NYU Dataset

    MPC309 Modulates Androgen Receptor Transcriptional Activity to Inhibit Therapy-Resistant Prostate Cancer

    Authors
    Justine Habault
    Jeffrey A. Schneider
    Susan Ha
    Rachel Ruoff
    14 more author(s)...
    Description

    Prostate cancer cells depend on the androgen receptor (AR) for survival and proliferation. This study examined the antitumor effects of compound MPC309, a trivalent display of ethisterone conjugated to a peptoid oligomer backbone that binds to the AR with nanomolar affinity. First, a structure-activity relationship study was performed to improve multivalent peptoid conjugate potency. Then, the impact...

    Subject
    Cancer
    Genomics
    Access Rights
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