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NYU Dataset
CpG Oligodeoxynucleotides Improves Alzheimer’s Disease Pathology in Aged Squirrel Monkeys
- Authors
- Akash G. PatelPramod N. NeheteSara R. KrivoshikXuewei Pei7 more author(s)...
- Description
Previous studies showed that harnessing innate immunity via CpG oligodeoxynucleotides (ODNs) modulates age-related defects. This study used elderly female squirrel monkeys as model of sporadic Alzheimer’s disease pathology. Current immunotherapeutic trials for Alzheimer’s disease have amyloid-related imaging flaws, which are linked to the presence of cerebral amyloid angiopathy (CAA). Therefore, the...
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NYU Dataset
Impairment of Visual Cortical Plasticity by Amyloid-Beta Species
- Authors
- Christopher M. WilliamMatthew A. SternXuewei PeiLubna Saqran3 more author(s)...
- Description
Alzheimer’s disease (AD) is characterized by accumulation of amyloid-beta (Aβ) in amyloid plaques and transgenic and knock-in mice that express mutant alleles of amyloid precursor protein (APP) have been used to model the effects of Aβ. This study examined visual system plasticity in transgenic mice that express and secrete Aβ throughout the brain in the absence of APP overexpression to explore the...
- Subject
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Neuroscience
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- Application RequiredAuthor Approval Required
