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NYU Dataset
KEAP1 Mutation in Lung Adenocarcinoma Promotes Immune Evasion and Immunotherapy Resistance
- Authors
- Anastasia-Maria ZavitsanouRay PillaiYuan HaoWarren L. Wu23 more author(s)...
- Description
Lung cancer is the leading cause of cancer related deaths worldwide and immunotherapy has become an important therapeutic intervention. Immunotherapy for lung cancer patients often fails with specific mutations like KEAP1. This study examined the impact of KEAP1 mutations on cancer growth and immune surveillance. They generated an orthotopic transplant model of KrasG12D/+; p53-/- lung cancer with cells...
- Subject
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CancerGenomics
- Access Rights
- Free to All
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NYU Dataset
Mapping the Landscape of Histomorphological Cancer Phenotypes Using Self-Supervised Learning on Unannotated Pathology Slides
- Authors
- Adalberto Claudio QuirosNicolas CoudrayAnna H. YeatonXinyu Yang12 more author(s)...
- Description
Histomorphological Phenotype Learning (HPL) was developed as a self-supervised methodology to discriminatory features in microscopy images to aid in cancer diagnosis and management. The methodology partitions whole slide images (WSIs) into meaningful Histomorphological Phenotype Clusters (HPCs) that can be used to define and quantify morphological phenotypes which recur within and between cases. HPL...
- Subject
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CancerChronic Disease
- Access Rights
- Free to AllAuthor Approval Required
