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  • NYU Dataset

    Novel pH Modulation of Lysosomes Through β2-Adrenergic Regulation of ClC-7 in Alzheimer’s Disease

    Authors
    Ju-Hyun Lee
    Devin M. Wolfe
    Sandipkumar Darji
    Mary Kate McBrayer
    5 more author(s)...
    Description

    Lysosomal dysfunction plays a key role in the pathogenesis of Alzheimer’s disease (AD) and Parkinson’s disease (PD). In early onset of AD, there is loss of Presenilin-1 (PSEN1) function. The loss of PSEN1 function impedes ER to lysosome delivery of chloride channel-7 (ClC-7). In murine blastocysts with different PSEN1 genotypes, isoproterenol and related β2-adrenergic agonists was used to reverse lysosomal...

    Subject
    Genomics
    Neuroscience
    Access Rights
    Free to All