NYU Data Catalog

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  • NYU Dataset

    RNA Recognition Mechanism that Governs Np4 Decapping by RppH

    Authors
    Rose Levenson-Palmer
    Daniel J. Luciano
    Nikita Vasilyev
    Ashok Nuthanakanti
    2 more author(s)...
    Description

    Dinucleoside tetraphosphates have been shown to function in bacteria as precursors to nucleoside tetraphosphate (Np4) RNA caps. The removal of this cap is critical for initiating 5′ end-dependent degradation of those RNAs, which affects bacterial adaptability to stress. This study described that the RNA pyrophosphohydrolase (RppH) assumes a leading role in decapping those transcripts in Escherichia...

    Subject
    Proteomics
    Access Rights
    Free to All
  • NYU Dataset

    Targeting KRAS(G12D) with Mutant-Selective Monobody Inhibitors

    Authors
    Padma Akkapeddi
    Takamitsu Hattori
    Imran Khan
    Eliezra Glasser
    11 more author(s)...
    Description

    This study developed a series of synthetic binding proteins called monobodies that are selective to KRAS(G12D). KRAS(G12D) is a common mutation associated with deadly cancers, such as pancreatic and colorectal cancers. Although recent discoveries have revealed that KRAS(G12D) is no longer undruggable, there are still few direct inhibitors selective to KRAS(G12D). The dataset contains structural coordinates...

    Subject
    Cancer
    Proteomics
    Access Rights
    Free to All