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  • NYU Dataset

    Structural Characterization of Monoclonal Antibodies Targeting Ser404 Region of Phosphorylated Tau Protein

    Authors
    Jessica E. Chukwu
    Erin E. Congdon
    Einar M. Sigurdsson
    Xiang-Peng Kong
    Description

    Tau is one of the major microtubule-associated proteins in neurons. Its main role is to stabilize microtubules, supporting cytoskeletal organization, and axonal transport. Tau may undergo pathological modifications and become hyperphosphorylated. This causes the protein to accumulate into toxic assemblies that collectively lead to neurodegeneration. In Alzheimer's disease, tau proteins change shape...

    Subject
    Neuroscience
    Proteomics
    Access Rights
    Free to All