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  • NYU Dataset

    Evolutionarily Central Synaptic Role of Ku, X4L4, and XLF in NHEJ Synapsis

    Authors
    Bailin Zhao
    Go Watanabe
    Michael J. Morten
    Dylan A. Reid
    2 more author(s)...
    Description

    NHEJ is the dominant double-strand break (DSB) repair pathway. During synapsis, the two DNA ends at a DSB are brought together into physical proximity for DNA repair. Using single-molecule FRET (smFRET), the study showed that both Ku and XRCC4:DNA ligase IV (X4L4) are necessary to achieve a flexible synapsis of blunt DNA ends. The addition of XLF causes a transition to a close synaptic state and the...

    Subject
    Genomics
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