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  • NYU Dataset

    Evaluating Everolimus Molecular Mechanisms in Tuberous Sclerosis Complex and Focal Cortical Dysplasia

    Authors
    Dominique F. Leitner
    Evgeny Kanshin
    Manor Askenazi
    Yik Siu
    6 more author(s)...
    Description

    Tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) are associated with dysfunctional mammalian target of rapamycin (mTOR) signaling, which results in increased cell growth and ribosomal S6 protein phosphorylation. TSC studies suggest mTOR inhibitors can reduce TSC tumor growth and seizure frequency, while FCD studies indicate seizure suppression. This study assessed safety of mTOR...

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