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NYU Dataset
Depupylase Dop Regulates Substrate Selectivity in Mycobacterium tuberculosis
- Authors
- Jin Hee YooShoshanna C. KahneK. Heran Darwin
- Description
Mycobacteria encode a prokaryotic ubiquitin-like protein that posttranslationally modifies proteins to mark them for proteolysis. Pupylation occurs on lysines of targeted proteins and is catalyzed by the ligase PafA. Like ubiquitylation, pupylation can be reversed by the depupylase Dop, which shares high structural similarity with PafA. Unique to Dop near its active site is a disordered loop of approximately...
- Subject
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Infectious DiseaseProteomics
- Access Rights
- Free to All