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  • NYU Dataset

    Volume Electron Microscopy Reveals Connexin43 in Plakophilin-2 Deficient Hearts

    Authors
    Chantal J. M. van Opbergen
    Joseph Sall
    Christopher Petzold
    Kristen Dancel-Manning
    2 more author(s)...
    Description

    Previous studies showed an abundance of functional Connexin43 (Cx43) hemichannels consequent to loss of plakophilin-2 (PKP2) expression in adult murine hearts. This study combined pre-embedding immunolabeling with serial block-face scanning electron microscopy (SBF-SEM) to visualize and examine the gap junction plaque morphology. They used a murine model of cardiomyocyte-specific Tamoxifen (TAM) activated...

    Subject
    Cell Physiology
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