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  • NYU Dataset

    Profiling Basal Forebrain Cholinergic Neurons Reveals Vulnerability Within the Mouse Model of Down Syndrome and Alzheimer’s Disease

    Authors
    Melissa J. Alldred
    Sai C. Penikalapati
    Sang Han Lee
    Adriana Heguy
    2 more author(s)...
    Description

    Basal forebrain cholinergic neuron (BFCN) degeneration is an indicator of Down syndrome (DS) and Alzheimer’s disease (AD). The Ts65Dn (Ts) mouse model recapitulates both cognitive and morphological deficits of DS and AD, including BFCN degeneration. Therefore, this study used Ts mice to understand mechanisms underlying BFCN degeneration to identify novel targets for therapeutic intervention. They performed...

    Subject
    Genomics
    Neuroscience
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    Author Approval Required
  • NYU Dataset

    Oxidative Phosphorylation Is Dysregulated Within the Basocortical Circuit in Mouse Model of Down Syndrome and Alzheimer’s Disease

    Authors
    Melissa J. Alldred
    Sang Han Lee
    Grace E. Stutzmann
    Stephen D. Ginsberg
    Description

    Neurological dysfunction associated with Down syndrome (DS) is the concomitant basal forebrain cholinergic neuron (BFCN) degeneration and onset of Alzheimer’s disease (AD) pathology. Previously, single population RNA sequencing analysis in the Ts65Dn (Ts) mouse model of DS revealed that the mitochondrial oxidative phosphorylation pathway was significantly impacted, where a large subset of genes within...

    Subject
    Neuroscience
    Proteomics
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    Author Approval Required
  • NYU Dataset

    Therapeutic Insights into Overcoming Therapy Resistance in BRAFV600E Melanoma

    Authors
    Ze-Yan Zhang
    Yingwen Ding
    Ravesanker Ezhilarasan
    Tenzin Lhakhang
    9 more author(s)...
    Description

    Although targeted cancer therapies have been successful, their efficacies are limited by the development of resistance driven by clonal evolution within tumors. This study developed a single-cell barcoding approach to comprehensively trace clonal dynamics and capture live lineage-coupled resistant cells for in-depth multi-omics analysis and functional exploration. They showed that heterogeneous clones,...

    Subject
    Cancer
    Genomics
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    Free to All