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  • NYU Dataset

    KaryoCreate: A CRISPR-Based Technology to Study Chromosome-Specific Aneuploidy

    Authors
    Nazario Bosco
    Aleah Goldberg
    Xin Zhao
    Joseph C. Mays
    24 more author(s)...
    Description

    This study described karyotype CRISPR engineered aneuploidy technology (KaryoCreate), a system that enables generation of chromosome-specific aneuploidies by co-expression of an sgRNA targeting chromosome-specific CENPA-binding ɑ-satellite repeats together with dCas9 fused to mutant KNL1. They designed unique and highly specific sgRNAs for 19 of the 24 chromosomes. To examine the activity of the predicted...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All