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NYU Dataset
Mechanism of Beta-Arrestin 1 Mediated Src Activation via Src SH3 Domain
- Authors
- Natalia PakharukovaBrittany N. ThomasHarsh BansiaLinus Li12 more author(s)...
- Description
Beta-arrestins (βarrs) are key transducers of G-protein coupled receptors, but the mechanisms of βarr signaling are poorly understood. Therefore, this study examined the structural mechanisms underlying βarr-mediated signal transduction. Using cryo-electron microscopy (cryo-EM), the study examined how βarr1 recruits and activates the non-receptor tyrosine kinase Src, a well-established signaling partner...
- Subject
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Proteomics
- Access Rights
- Free to All
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NYU Dataset
Proximity Labeling Identifies BIRC6 as a Ubiquitin Ligase for KRAS4A
- Authors
- Juan Kochen RossiCristina Nuevo-TapiolesRachel A. O’KeefeMoritz Hunkeler11 more author(s)...
- Description
KRAS is a frequently mutated oncogene in human cancers and a critical driver of high-mortality cancers such as lung, colon, and pancreatic adenocarcinoma. Recent advances in drug design have led to the development of multiple strategies to inactivate KRAS. Therefore, this study performed proximity labeling to map the differential interactomes of the KRAS splice variants, KRAS4A and KRAS4B. Among the...
- Subject
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CancerProteomics
- Access Rights
- Free to All