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  • NYU Dataset

    Mechanism of Beta-Arrestin 1 Mediated Src Activation via Src SH3 Domain

    Authors
    Natalia Pakharukova
    Brittany N. Thomas
    Harsh Bansia
    Linus Li
    12 more author(s)...
    Description

    Beta-arrestins (βarrs) are key transducers of G-protein coupled receptors, but the mechanisms of βarr signaling are poorly understood. Therefore, this study examined the structural mechanisms underlying βarr-mediated signal transduction. Using cryo-electron microscopy (cryo-EM), the study examined how βarr1 recruits and activates the non-receptor tyrosine kinase Src, a well-established signaling partner...

    Subject
    Proteomics
    Access Rights
    Free to All