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  • NYU Dataset

    Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

    Authors
    Sisi Chen
    Rahul S. Vedula
    Antonio Cuevas-Navarro
    Bin Lu
    23 more author(s)...
    Description

    This study demonstrated that loss of LZTR1, or leukemia-associated mutants in the LZTR1 substrate and RAS GTPase RIT1 that escape degradation, drives hematopoietic stem cell expansion and leukemia in vivo. For the study, genome-scale CRISPR/Cas9 screen performed in different variants of the TF-1 cell line genetically-modified to express mutant forms of RIT1 (M90I or F82C) or depleted in LZTR1 by CRISPR/Cas9,...

    Subject
    Cancer
    Genomics
    Access Rights
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