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  • NYU Dataset

    Oxidative Phosphorylation Is Dysregulated Within the Basocortical Circuit in Mouse Model of Down Syndrome and Alzheimer’s Disease

    Authors
    Melissa J. Alldred
    Sang Han Lee
    Grace E. Stutzmann
    Stephen D. Ginsberg
    Description

    Neurological dysfunction associated with Down syndrome (DS) is the concomitant basal forebrain cholinergic neuron (BFCN) degeneration and onset of Alzheimer’s disease (AD) pathology. Previously, single population RNA sequencing analysis in the Ts65Dn (Ts) mouse model of DS revealed that the mitochondrial oxidative phosphorylation pathway was significantly impacted, where a large subset of genes within...

    Subject
    Neuroscience
    Proteomics
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