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  • NYU Dataset

    Targeting KRAS(G12D) with Mutant-Selective Monobody Inhibitors

    Authors
    Padma Akkapeddi
    Takamitsu Hattori
    Imran Khan
    Eliezra Glasser
    11 more author(s)...
    Description

    This study developed a series of synthetic binding proteins called monobodies that are selective to KRAS(G12D). KRAS(G12D) is a common mutation associated with deadly cancers, such as pancreatic and colorectal cancers. Although recent discoveries have revealed that KRAS(G12D) is no longer undruggable, there are still few direct inhibitors selective to KRAS(G12D). The dataset contains structural coordinates...

    Subject
    Cancer
    Proteomics
    Access Rights
    Free to All