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NYU Dataset
Targeting KRAS(G12D) with Mutant-Selective Monobody Inhibitors
- Authors
- Padma AkkapeddiTakamitsu HattoriImran KhanEliezra Glasser11 more author(s)...
- Description
This study developed a series of synthetic binding proteins called monobodies that are selective to KRAS(G12D). KRAS(G12D) is a common mutation associated with deadly cancers, such as pancreatic and colorectal cancers. Although recent discoveries have revealed that KRAS(G12D) is no longer undruggable, there are still few direct inhibitors selective to KRAS(G12D). The dataset contains structural coordinates...
- Subject
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CancerProteomics
- Access Rights
- Free to All
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NYU Dataset
Intra-Serotype Variation of Streptococcus pneumoniae Capsule
- Authors
- Hannes EichnerCindy WuMichael CammerElizabeth N. H. Tran3 more author(s)...
- Description
Streptococcus pneumoniae (S. pneumoniae) remains a leading cause of respiratory and invasive diseases despite the availability of vaccines. These vaccines target a polysaccharide capsule the bacterium uses to evade the immune system. Variation of the capsule composition subdivides the organism into serotypes and influences its protective potency. It is commonly assumed that S. pneumoniae strains of...
- Subject
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AnatomyInfectious Disease
- Access Rights
- Free to All