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  • NYU Dataset

    Protemic Data Indicates Altered Steady State and De Novo Protein Expression in Fragile X Syndrome

    Authors
    Heather Bowling
    Aditi Bhattacharya
    Guoan Zhang
    Danyal Alam
    13 more author(s)...
    Description

    Fragile X syndrome (FXS) is caused by changes in FMR1 gene, which leads to transcriptional silencing and loss of its protein product fragile X mental retardation protein (FMRP). For this study, proteomic experiments were performed to investigate the de novo translational profile in FXS model mice is altered at steady state and in response to metabotropic glutamate receptor (mGluR) stimulation. Altered...

    Subject
    Genomics
    Proteomics
    Access Rights
    Free to All

  • Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Idiopathic Autism Spectrum Disorder and Fragile X Syndrome

    Authors
    James Robert Brasic
    Ayon Nandi
    David S. Russell
    Danna Jennings
    7 more author(s)...
    Description

    Prior studies have linked dysfunction of metabotropic glutamate receptors (mGluR) to idiopathic autism spectrum disorder (IASD) and fragile X syndrome (FXS). In this study, the investigators evaluated mGluR5 expression in participants with IASD, FXS, and typical development (TD) using positron emission tomography (PET). The Institute for Neurodegenerative Disorders (IND) in New Haven, Connecticut enrolled...

    Subject
    Neuroscience
    Access Rights
    Free to All