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  • NYU Dataset

    Therapeutic Insights into Overcoming Therapy Resistance in BRAFV600E Melanoma

    Authors
    Ze-Yan Zhang
    Yingwen Ding
    Ravesanker Ezhilarasan
    Tenzin Lhakhang
    9 more author(s)...
    Description

    Although targeted cancer therapies have been successful, their efficacies are limited by the development of resistance driven by clonal evolution within tumors. This study developed a single-cell barcoding approach to comprehensively trace clonal dynamics and capture live lineage-coupled resistant cells for in-depth multi-omics analysis and functional exploration. They showed that heterogeneous clones,...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All