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Results Found: 5
  • NYU Dataset

    Correlation Between Autoimmunity to Phosphatidylserine and Anemia in African Trypanosome Infections

    Authors
    Juan Rivera-Correa
    Joseph Verdi
    Julian Sherman
    Jeremy M. Sternberg
    2 more author(s)...
    Description

    Anemia is a common complication in many infectious diseases, including protozoan parasitic infections. Trypanosomes are eukaryotic parasites and most relevant human trypanosome pathogens are Trypanosoma brucei and Trypanosoma cruzi. Autoimmunity during Trypanosoma brucei infection is indicated to have a role during anemia, but anemia caused by trypanosome infection is poorly understood. In mouse models...

    Subject
    Infectious Disease
    Access Rights
    Free to All
  • NYU Dataset

    CpG Oligodeoxynucleotides Improves Alzheimer’s Disease Pathology in Aged Squirrel Monkeys

    Authors
    Akash G. Patel
    Pramod N. Nehete
    Sara R. Krivoshik
    Xuewei Pei
    7 more author(s)...
    Description

    Previous studies showed that harnessing innate immunity via CpG oligodeoxynucleotides (ODNs) modulates age-related defects. This study used elderly female squirrel monkeys as model of sporadic Alzheimer’s disease pathology. Current immunotherapeutic trials for Alzheimer’s disease have amyloid-related imaging flaws, which are linked to the presence of cerebral amyloid angiopathy (CAA). Therefore, the...

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  • NYU Dataset

    Brain Insulin Resistance in Subjects with Major Depressive Disorder

    Authors
    Carla Nasca
    Josh Dobbin
    Benedetta Bigio
    Kathleen Watson
    9 more author(s)...
    Description

    Previous studies in rodent showed impaired brain insulin signaling with resultant insulin resistance (IR) modulates synaptic plasticity and the corresponding behavioral functions. This study investigated whether brain enriched exosomes and brain IR differ between subjects with major depressive disorder (MDD) and respective controls. They also examined potential sex differences in circulating brain...

    Subject
    Neuroscience
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  • NYU Dataset

    Anti-DNA and Anti-Phosphatidylserine Antibodies Predicted Development of Severe COVID-19

    Authors
    Claudia Gomes
    Marisol Zuniga
    Kelly A. Crotty
    Kun Qian
    11 more author(s)...
    Description

    This is a retrospective cohort study of COVID-19 hospitalized patients with different degrees of severity. They performed this study to analyze the generation of autoimmune antibodies to common antigens. This study included 115 hospitalized patients with SARS-CoV-2 infection and 42 uninfected controls. Sample collection was performed as part of routine clinical care for COVID-19 patients at the time...

    Subject
    COVID-19
    Infectious Disease
    Timeframe
    2020
    Access Rights
    Free to All
  • NYU Dataset

    Autoimmunity to Annexin A2 Predicts Mortality Among Hospitalised COVID-19 Patients

    Authors
    Marisol Zuniga
    Claudia Gomes
    Steven E. Carsons
    Michael T. Bender
    4 more author(s)...
    Description

    This study examined autoimmune antibodies to annexin A2, which is a phospholipid-binding protein expressed in the lung and other organs, in COVID-19 patients. Annexin A2 is critical for fibrinolysis, lung elasticity, cell membrane repair, and integrity of the pulmonary vasculature. Therefore, antagonism of annexin A2 may explain many of the clinical features of severe COVID-19 cases. This study analyzed...

    Subject
    COVID-19
    Infectious Disease
    Access Rights
    Application Required
    Author Approval Required