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  • NYU Dataset

    Proximity Labeling Identifies BIRC6 as a Ubiquitin Ligase for KRAS4A

    Authors
    Juan Kochen Rossi
    Cristina Nuevo-Tapioles
    Rachel A. O’Keefe
    Moritz Hunkeler
    11 more author(s)...
    Description

    KRAS is a frequently mutated oncogene in human cancers and a critical driver of high-mortality cancers such as lung, colon, and pancreatic adenocarcinoma. Recent advances in drug design have led to the development of multiple strategies to inactivate KRAS. Therefore, this study performed proximity labeling to map the differential interactomes of the KRAS splice variants, KRAS4A and KRAS4B. Among the...

    Subject
    Cancer
    Proteomics
    Access Rights
    Free to All