NYU Data Catalog

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  • NYU Dataset

    Structural Basis of Ion-Substrate Coupling in the Sodium-Dependent Dicarboxylate Transporter VcINDY

    Authors
    David B. Sauer
    Jennifer J. Marden
    Joseph C. Sudar
    Jinmei Song
    2 more author(s)...
    Description

    VcINDY is a sodium-dependent dicarboxylate transporter that imports tricarboxylic acid cycle intermediates across the inner membrane of Vibrio cholerae. This study used a combination of structure determination by single-particle cryo-electron microscopy, substrate-binding affinity measurements by intrinsic tryptophan fluorescence quenching, and position accessibility quantification by site-directed...

    Subject
    Proteomics
    Access Rights
    Free to All
  • NYU Dataset

    Targeting KRAS(G12D) with Mutant-Selective Monobody Inhibitors

    Authors
    Padma Akkapeddi
    Takamitsu Hattori
    Imran Khan
    Eliezra Glasser
    11 more author(s)...
    Description

    This study developed a series of synthetic binding proteins called monobodies that are selective to KRAS(G12D). KRAS(G12D) is a common mutation associated with deadly cancers, such as pancreatic and colorectal cancers. Although recent discoveries have revealed that KRAS(G12D) is no longer undruggable, there are still few direct inhibitors selective to KRAS(G12D). The dataset contains structural coordinates...

    Subject
    Cancer
    Proteomics
    Access Rights
    Free to All