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NYU Dataset
Volume Electron Microscopy Reveals Connexin43 in Plakophilin-2 Deficient Hearts
- Authors
- Chantal J. M. van OpbergenJoseph SallChristopher PetzoldKristen Dancel-Manning2 more author(s)...
- Description
Previous studies showed an abundance of functional Connexin43 (Cx43) hemichannels consequent to loss of plakophilin-2 (PKP2) expression in adult murine hearts. This study combined pre-embedding immunolabeling with serial block-face scanning electron microscopy (SBF-SEM) to visualize and examine the gap junction plaque morphology. They used a murine model of cardiomyocyte-specific Tamoxifen (TAM) activated...
- Subject
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Cell Physiology
- Access Rights
- Application RequiredAuthor Approval Required
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NYU Dataset
RAS-Dependent Mitogen-Activated Protein Kinase Hyperactivation by Pathogenic RIT1
- Authors
- Antonio Cuevas-NavarroMorgan WagnerRichard VanMonalisa Swain11 more author(s)...
- Description
The RAS family of small guanosine triphosphatases (GTPases) control a diverse network of signaling pathways essential for human development and adult tissue homeostasis. RAS-related GTPase RIT1 proteins promote mitogen-activated protein kinase (MAPK) hyperactivation, but this mechanism remains poorly understood. This study examined whether MEK1/2 inhibition attenuates MAPK signaling in RIT1 M90I mice...
- Subject
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CancerGenomics
- Access Rights
- Free to All
